NDLI: Point process models show temporal dependencies of basal ganglia nuclei under Deep Brain Stimulation

Content Provider	IEEE Xplore Digital Library
Author	Saxena, S. Santaniello, S. Montgomery, E.B. Gale, J.T. Sarma, S.V.
Copyright Year	2010
Description	Author affiliation: Department of Neurosurgery, Harvard Medical School, USA (Montgomery, E.B.) \|\| Department of Biomedical Engineering, Johns Hopkins University, USA (Saxena, S.; Santaniello, S.; Sarma, S.V.) \|\| Department of Neurology, School of Medicine, University of Alabama at Birmingham, USA (Gale, J.T.)
Abstract	Deep Brain Stimulation (DBS) is an effective treatment for patients with Parkinsons disease, but its impact on basal ganglia nuclei is not fully understood. DBS applied to the subthalamic nucleus (STN) affects neurons in the Globus Pallidus pars interna (GPi) through direct projections, as well as indirectly through the Globus Pallidus pars externa (GPe). Since traditional statistical analyses of electrophysiological data provide too coarse a view of circuit dynamics, and mesoscopic biophysical dynamic models contain an intractable number of state variables for small populations of neurons, we apply a modular approach and treat each region in the STN-GPe-GPi circuit as a multi-input multi-output point process system. We use microelectrode recordings of a normal primate with DBS applied to STN at 100 and 130 Hz to estimate point process models (PPMs) for recorded regions in GPi. Our PPMs uncovered distinct dependencies between regions of GPe and GPi neurons, separated by the position of the GPi neurons, and showed normal refractory periods, inhibition from projecting neurons in the GPe, and DBS-induced oscillatory effects. The PPMs also showed the relative impact of the above factors, which traditional statistics fail to capture. Our PPM framework suggests a useful approach for understanding dynamics of complex neural circuits.
Starting Page	4152
Ending Page	4155
File Size	745545
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5627350
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neurons Satellite broadcasting History Analytical models Computational modeling Basal ganglia Brain stimulation
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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