NDLI: Functional regeneration of severed peripheral nerve using an implantable electrical stimulator

Content Provider	IEEE Xplore Digital Library
Author	Tae Hyung Lee Hui Pan In Sook Kim Soon Jung Hwang Kim, S.J.
Copyright Year	2010
Description	Author affiliation: School of Electrical Engineering and Computer Science, Seoul National University, Republic of Korea (Tae Hyung Lee; Kim, S.J.) \|\| Department of Oral And Maxillofacial Surgery, School of Dentistry, Seoul National University, Republic of Korea (Hui Pan; Soon Jung Hwang) \|\| Dental Research Institute, Seoul National University, Republic of Korea (In Sook Kim)
Abstract	This paper presents functional regeneration of severed peripheral nerve using a polymer-based implantable electrical stimulator. A polyimide based conduit electrode was made by micro-fabrication and a stimulation chip was designed to generate biphasic current pulse for electrical stimulation. The stimulation chip was packaged with a battery using silicone elastomer, and integrated with the electrode. The implantable electrical stimulator was implanted in the rat sciatic nerve with 7 mm gap. The electrical stimulation was applied for periods of one, two and four weeks between the proximal and the distal nerve stumps. After four weeks of post-operations, the degree of regeneration was evaluated through walking track assessments and by measuring neural response of the regenerated nerve. Based on these results, electrical stimulation, especially for two weeks of stimulation, could accelerate functional regeneration of the severed nerve.
Starting Page	1511
Ending Page	1514
File Size	841197
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5626837
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Electrical stimulation Rats Injuries Legged locomotion Polyimides
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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