NDLI: Modeling the motor striatum under Deep Brain Stimulation in normal and MPTP conditions

Content Provider	IEEE Xplore Digital Library
Author	Santaniello, S. Gale, J.T. Montgomery, E.B. Sarma, S.V.
Copyright Year	2010
Description	Author affiliation: Institute of Computational Medicine, Johns Hopkins University, Baltimore, MD 21218 USA (Santaniello, S.; Sarma, S.V.) \|\| Department of Neurosciences, Cleveland Clinic, 44195, OH, USA (Gale, J.T.) \|\| Department of Neurology, University of Alabama at Birmingham, 35294 USA (Montgomery, E.B.)
Abstract	Striatum (STR) is the major input stage of the basal ganglia (BG). It combines information from cortex, subthalamic nucleus (STN) and external globus pallidus (GPe), and projects to the output stages of the BG, where selection between concurrent motor programs is performed. Parkinson's disease (PD) reduces the concentration of dopamine (DA, a neurotransmitter) in STR and changes in the level of DA correlate with the onset of PD motor disorders. Though STR plays a pivotal role in BG, its behavior under PD and Deep Brain Stimulation (DBS) is still unclear. We develop point-process models of the STR neurons as a function of the activity in GPe, cortex, and DBS. We use single unit recordings from a monkey under STN DBS at different frequencies before and after treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine (MPTP) to develop PD motor symptoms. The models suggest that STR neurons have prominent bursting activity in normal conditions, positive correlation with cortex (3–10 ms delay), and mild negative correlation with GPe (1–5 ms lag). DA depletion evokes 30–60 Hz oscillations, and increases the propensity of each neuron to be inhibited by surrounding neurons. DBS elicits antidromical activation, masks existent dynamics, reinforces dependencies between nuclei, and entrains at the stimulation frequency in both conditions.
Starting Page	2065
Ending Page	2068
File Size	442804
Page Count	4
File Format	PDF
ISBN	9781424441235
ISSN	1557170X
DOI	10.1109/IEMBS.2010.5626354
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-31
Publisher Place	Argentina
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Neurons Satellite broadcasting History Oscillators Brain models Discharges
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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