NDLI: Dynamics of the extended subthalamic-pallidal complex in deep brain stimulation for Parkinson's disease

Content Provider	IEEE Xplore Digital Library
Author	Xue Zhiqin Wang Jiang Yu Haitao
Copyright Year	2012
Description	Author affiliation: School of Electrical Engineering and Automation, Tianjin University, Tianjin, 300072, China (Xue Zhiqin; Wang Jiang; Yu Haitao)
Abstract	We extend the simple firing-rate model of the complex, composed of the subthalamic nucleus (STN) and the external segment of the globus pallidus (GPe), by introducing the internal segment of the globus pallidus (GPi) to investigate the dynamics of the basal ganglia system (BGS). Through numerical simulation we show that, the system can reproduce both the physiological and pathological state of the subthalamo-pallidal complex. Furthermore, the dynamics of the extended complex in deep brain stimulation (DBS) for Parkinson's disease (PD) is also studied. It is shown that high frequency stimulation of STN can regularize the GPi firing, and functionally restore TC responsiveness. We also find that low frequency DBS can also alleviate the motor symptoms caused by a weakening of intra-GPe connections. The presented results could have important implications for understanding the underlying mechanisms of DBS.
Starting Page	7393
Ending Page	9397
File Size	473000
Page Count	2005
File Format	PDF
ISBN	9781467325813
ISSN	21612927
e-ISBN	9789881563811
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-07-25
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Chinese Assoc of Automati
Subject Keyword	Pathology Basal ganglia Firing Parkinson's disease Satellite broadcasting Neurons firing-rate model subthalamic-pallidal complex Oscillators deep brain stimulation Diseases
Content Type	Text
Resource Type	Article

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