NDLI: Simulation of cellular changes on Optical Coherence Tomography of human retina

Content Provider	IEEE Xplore Digital Library
Author	Santos, M. Araujo, A. Barbeiro, S. Caramelo, F. Correia, A. Marques, M.I. Pinto, L. Serranho, P. Bernardes, R. Morgado, M.
Copyright Year	2015
Description	Author affiliation: Dept. of Math., Univ. of Coimbra, Coimbra, Portugal (Araujo, A.; Barbeiro, S.; Pinto, L.) \|\| Fac. of Med., Univ. of Coimbra, Coimbra, Portugal (Caramelo, F.; Marques, M.I.; Serranho, P.; Bernardes, R.; Morgado, M.) \|\| AIBILI-Assoc. for Innovation & Biomed. Res. on Light & Image, Coimbra, Portugal (Santos, M.; Correia, A.)
Abstract	We present a methodology to assess cell level alterations on the human retina responsible for functional changes observable in the Optical Coherence Tomography data in healthy ageing and in disease conditions, in the absence of structural alterations. The methodology is based in a 3D multilayer Monte Carlo computational model of the human retina. The optical properties of each layer are obtained by solving the Maxwell's equations for 3D domains representative of small regions of those layers, using a Discontinuous Galerkin Finite Element Method (DG-FEM). Here we present the DG-FEM Maxwell 3D model and its validation against Mie's theory for spherical scatterers. We also present an application of our methodology to the assessment of cell level alterations responsible for the OCT data in Diabetic Macular Edema. It was possible to identify which alterations are responsible for the changes observed in the OCT scans of the diseased groups.
Starting Page	8147
Ending Page	8150
File Size	502918
Page Count	4
File Format	PDF
ISSN	1557170X
e-ISBN	9781424492718
DOI	10.1109/EMBC.2015.7320285
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-08-25
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Retina Optical scattering Optical imaging Mathematical model Three-dimensional displays Coherence
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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