NDLI: Nanosecond pulsed electric field ablation of hepatocellular carcinoma

Content Provider	IEEE Xplore Digital Library
Author	Beebe, S.J. Xinhua Chen Liu, J.A. Schoenbach, K.H.
Copyright Year	2011
Description	Author affiliation: Frank Reidy Research Center for Bioelectrics and the Department of Biology at Old Dominion University, Norfolk, VA (Xinhua Chen) \|\| Frank Reidy Research Center for Bioelectrics and the Department of Biology at Old Dominion University, Norfolk, VA 23508, USA (Liu, J.A.) \|\| Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508 USA (Beebe, S.J.; Schoenbach, K.H.)
Abstract	Hepatocellular carcinoma often evades effective therapy and recurrences are frequent. Recently, nanosecond pulsed electric field (nsPEF) ablation using pulse power technology has emerged as a local-regional, non-thermal, and non-drug therapy for skin cancers. In the studies reported here we use nsPEFs to ablate murine, rat and human HCCs in vitro and an ectopic murine Hepa 1–6 HCC in vivo. Using pulses with 60 or 300 ns and electric fields as high as 60 kV/cm, murine Hepa 1–6, rat N1S1 and human HepG2 HCC are readily eliminated with changes in caspase-3 activity. Interestingly caspase activities increase in the mouse and human model and decrease in the rat model as electric field strengths are increased. In vivo, while sham treated control mice survived an average of 15 days after injection and before humane euthanasia, Hepa 1–6 tumors were eliminated for longer than 50 days with 3 treatments using one hundred pulses with 100 ns at 55 kV/cm. Survival was 40% in mice treated with 30 ns pulses at 55 kV/cm. This study demonstrates that nsPEF ablation is not limited to effectively treating skin cancers and provides a rationale for treating orthotopic hepatocellular carcinoma in pre-clinical applications and ultimately in clinical trials.
Starting Page	6861
Ending Page	6865
File Size	542616
Page Count	5
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6091692
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Tumors Electric fields Mice Cancer Humans Liver Needles
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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