NDLI: Slowed propagation across the compacta-trabeculata interface: A consequence of fiber and sheet anisotropy

Content Provider	IEEE Xplore Digital Library
Author	Gilbert, S.H. Benson, A.P. Walton, R.D. Bernus, O.
Copyright Year	2011
Description	Author affiliation: Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, United Kingdom (Gilbert, S.H.; Benson, A.P.; Walton, R.D.; Bernus, O.)
Abstract	Transmural myocardial activation is influenced by myocardial structure, including structural differences between the compacta (Cta) and the trabeculata (Tta), although this has not been fully explained. Hearts from rats were Langendorff perfused, stained with DI-4-ANEPPS, the apex was cut off and fluorescence acquired from the exposed short-axis surface. The hearts were stimulated at 160 ms cycle length at the anterior, lateral, posterior left ventricle (LV) and septal sub-epicardial sites. Conduction velocity perpendicular to the wave front orientation was measured in each pixel using a gradient-based approach. After optical mapping the cut surface was imaged using a light microscope and the extent of the Cta and Tta mapped and validated against 50 u, m isotropic MRI images. We used a 3D rat ventricle computational model, with architecture obtained from 200 u, m isotropic diffusion tensor MRI and kinetics from the modified Pandit model to determine the relative roles of fibers and sheets on propagation. We show in the experimental study that circumferential propagation around the LV cavity is fast in the Cta: 63.2±19.5 and is slower in the Tta: $32.7±11.0^{∗}$ (mean ± s.d cms−1, ∗ p < 0.01 by two sample t test). In the simulation study the pattern and velocity are not replicated in an isotropic model (I), are partially replicated in a simulation study including fiber anisotropy (A) and is more fully replicated in orthotropic (O) ventricles (fiber and sheet anisotropy), where the circumferential propagation velocity is, I: Cta: 54.2±3.9; Tta:54.3±3.9; A: Cta:43.6±3.2; Tta: 40.6±6.6; O: Cta: 63.2±19.5; Tta: $32.7±11.9^{∗}.$ We show that sheet orientation is important in understanding activation differences between Cta and Tta.
Starting Page	1688
Ending Page	1692
File Size	2299833
Page Count	5
File Format	PDF
ISBN	9781424441211
ISSN	1557170X
e-ISBN	9781457715891
e-ISBN	9781424441228
DOI	10.1109/IEMBS.2011.6090485
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-08-30
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Myocardium Heart Computational modeling Optical imaging Optical fibers Anisotropic magnetoresistance
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Cardiac fiber rotation distorts surface measurements of anisotropic propagation

Arrhythmogenesis Research: A Perspective from Computational Electrophysiology Viewpoint

Diffusion Tensor MRI Study of Myocardium Structural Remodeling after Infarction in Porcine Model

ST elevation or depression in subendocardial ischemia?

Goniometric measurement for the estimation of anisotropy coefficient of human and animal pancreas

Hyperspectroscopic imager for baby fibers

The Effect of Fiber Orientation on Volume Measurement using Conductance Catheter Techniques

Optical mapping of optically paced embryonic hearts

Engineering of Fiber-Reinforced Tissues with Anisotropic Biodegradable Nanofibrous Scaffolds

Slowed propagation across the compacta-trabeculata interface: A consequence of fiber and sheet anisotropy

Similar Documents

Cardiac fiber rotation distorts surface measurements of anisotropic propagation

Arrhythmogenesis Research: A Perspective from Computational Electrophysiology Viewpoint

Diffusion Tensor MRI Study of Myocardium Structural Remodeling after Infarction in Porcine Model

ST elevation or depression in subendocardial ischemia?

Goniometric measurement for the estimation of anisotropy coefficient of human and animal pancreas

Hyperspectroscopic imager for baby fibers

The Effect of Fiber Orientation on Volume Measurement using Conductance Catheter Techniques

Optical mapping of optically paced embryonic hearts

Engineering of Fiber-Reinforced Tissues with Anisotropic Biodegradable Nanofibrous Scaffolds

Slowed propagation across the compacta-trabeculata interface: A consequence of fiber and sheet anisotropy