NDLI: Tests on a virtual patient for an observer-based, closed-loop control of plasma glycemia

Content Provider	IEEE Xplore Digital Library
Author	Palumbo, P. Pizzichelli, G. Panunzi, S. Pepe, P. De Gaetano, A.
Copyright Year	2011
Description	Author affiliation: Istituto di Analisi dei Sistemi ed Informatica “A. Ruberti”, Consiglio Nazionale delle Ricerche (IASI-CNR), BioMatLab - UCSC - Largo A. Gemelli 8, 00168 Roma, Italy (Palumbo, P.; Pizzichelli, G.; Panunzi, S.; De Gaetano, A.) \|\| Dipartimento di Ingegneria Elettrica e dell'Informazione, Universitá degli Studi dell'Aquila, 67040 Poggio di Roio, L'Aquila, Italy (Pepe, P.)
Abstract	Exogenous insulin administration is the basic way to face the widespread disease of Diabetes Mellitus. To this aim, closed-loop approaches, though theoretically realizable according to the control theory results and to the recent technology concerning continuous glucose measurements and affordable insulin infusion pumps, require a careful and thorough testing ground on a virtual environment before arranging an in-vivo clinical setting of experiments. In this work, a model-based control law for the plasma glycemia, recently published by the same authors, is evaluated by closing the loop on a virtual patient, whose model equations are different from the ones used to synthesize the control law. That means: a minimal model of the glucose-insulin system to design the insulin therapy, and a different, more detailed, comprehensive model to test in silico the control scheme. Uncertainties on the blood glucose measurements, as well as malfunctioning on the insulin delivery devices are considered, according to the standard technology, in order to obtain an effective benchmark for the closed-loop control and to show in fact the robustness of the proposed approach.
Starting Page	6936
Ending Page	6941
File Size	288715
Page Count	6
File Format	PDF
ISBN	9781612848006
ISSN	07431546
e-ISBN	9781612848013
e-ISBN	9781612847993
DOI	10.1109/CDC.2011.6160534
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-12-12
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Insulin Sugar Mathematical model Plasmas Diabetes Measurement uncertainty Plasma measurements
Content Type	Text
Resource Type	Article
Subject	Control and Optimization Control and Systems Engineering Modeling and Simulation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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