NDLI: Design Methodology for synthetic biosystems

Content Provider	IEEE Xplore Digital Library
Author	Madec, M. Lallement, C. Gendrault, Y. Haiech, J.
Copyright Year	2010
Description	Author affiliation: Institut d'electronique du Solide et des Systèmes (InESS), UMR 7163 - CNRS / UdS, 23, rue du Loess, 67037 Strasbourg Cedex 02 (France) (Madec, M.; Lallement, C.; Gendrault, Y.) \|\| Laboratoire d'Innovation Thérapeutique (LIT), UMR 7200 - CNRS / UdS, 74, route du Rhin, 67400 Illkirch (France) (Haiech, J.)
Abstract	Synthetic biology is an emerging area of biotechnology for which main applications are in the field of Health and Environment. However, it suffers from a lack of adapted CAD tools and methodology in order to fulfill efficiently and quickly to the needs of these domains. In this paper, the strong relationship between circuits design in microelectronics and synthetic biology is highlighted. Most of synthesized biodevices behavior can be interpreted and modeled by a “biologic gate”. As a consequence, bigger biosystems might be designed using methods and tools borrowed from microelectronics. These similarities lead to an efficient methodology, using microelectronics design flow, tools and methods, which should allow a top-down approach in synthetic biosystem design. The methodology is illustrated on the design of a biosystem (a T-flipflop), using top-down approach and HDL modeling languages. The proposed methods and its evolution prospects are discussed at the end of the paper.
Starting Page	621
Ending Page	626
File Size	780655
Page Count	6
File Format	PDF
ISBN	9781424470112
e-ISBN	9788392875642
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-06-24
Publisher Place	Poland
Access Restriction	Subscribed
Rights Holder	DEPT OF MICROELECTRON
Subject Keyword	Proteins biological NOR gate HDL design flow Biological system modeling biological flip-flop Logic gates Synthetic biology Microelectronics Mathematical model Biological information theory top-down
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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