NDLI: Point-of-Care Noninvasive Hemoglobin Determination Using Fiber Optic Reflectance Spectroscopy

Content Provider	IEEE Xplore Digital Library
Author	Jay, G.D. Racht, J. McMurdy, J. Mathews, Z. Hughes, A. Suner, S. Crawford, G.
Copyright Year	2007
Description	Author affiliation: Brown Univ., Providence (Jay, G.D.)
Abstract	Study objective: rapidly identifying anemia through qualitative observation of the palpebral conjunctiva for pallor is standard medical practice. We report on the ability of using a fiber optic array probe to collect diffusely reflected light from the palpebral conjunctiva and measure hemoglobin concentration noninvasively. Patients (N=102) admitted to the emergency department and receiving a complete blood count (CBQ were enrolled as a convenience set. The tarsal plate was exposed by averting the lower eyelid and illuminated with a white LED while diffusely reflected light was collected using a fiber optic probe and commercial grating spectrometer. Spectra were analyzed using partial least squares regression to extract hemoglobin concentration information and compare to the CBC result. The probe and algorithm demonstrated correlation coefficient of r = 0.82 and standard error of 1.05 g/dL compared to invasive CBC test. Experimental error is due to variability in distance and position of the probe relative to the conjunctiva. This technique has shown the ability to measure total hemoglobin noninvasively and in real-time at the point-of-care using diffuse reflectance spectroscopy of the tarsal plate, leading to potential inclusion of this class of device as a triage centric tool to identify anemia appearing with internal hemorrhage or other acute conditions.
Starting Page	2932
Ending Page	2935
File Size	275859
Page Count	4
File Format	PDF
ISBN	9781424407873
ISSN	1557170X
DOI	10.1109/IEMBS.2007.4352943
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-08-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Optical fibers Reflectivity Spectroscopy Probes Optical arrays Blood Eyelids Light emitting diodes Fiber gratings Information analysis
Content Type	Text
Resource Type	Article
Subject	Signal Processing Biomedical Engineering Health Informatics Computer Vision and Pattern Recognition

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