NDLI: Researching on Selectivity Mechanism of Potassium Channel to Monovalent Cations in Signal Transduction

Content Provider	IEEE Xplore Digital Library
Author	Yong Zhan Hailong An Suhua Zhang Hui Yu Yizhong Zhuo
Copyright Year	2005
Description	Author affiliation: Sch. of Sci., Hebei Univ. of Technol., Tianjin (Yong Zhan; Hailong An; Suhua Zhang; Hui Yu)
Abstract	Ion channels bear the same relation to electrical signaling in nerve, muscle, and synapse as enzymes bear to metabolism. The potassium channel is one of the most important type. Potassium ion is at least 10,000 times more permeant than sodium ion, remaining to be an open question of potassium channels. To elucidate the mechanism of ion selectivity at atomic level, the authors performed density functional theory to calculate the position energy on the basis of the X-ray structure of the KcsA channel. In the viewpoint of statistic thermodynamics, the two most readily permeant ions, potassium and rubidium ions, can pass through the selectivity filter. In contrast, sodium ions are preferring to stay in site 2 which can not pass through the channel. The energy barrier difference between the potassium ion and sodium ion is 35.15 kcal $mo/^{-1}.$ The energy barrier difference between the potassium ion and rubidium ion is 14.44 kcal $mol^{-1}$ . The energy barrier difference between the potassium ion and ammonium ion is 21.97 kcal $mol^{-1}.$ The results are qualitatively consistent with the experimental data. It is remarkable that the system, involving in 269 atoms, is much lower than the system involved in MD simulation which is on the order of 41000 atoms
Starting Page	1182
Ending Page	1184
File Size	253826
Page Count	3
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616634
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Filters Biomembranes Energy barrier Cells (biology) Electric potential Biochemistry Proteins Muscles Density functional theory Statistics
Content Type	Text
Resource Type	Article

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