NDLI: Virtual modelling of compartmental pharmacokinetic systems

Content Provider	IEEE Xplore Digital Library
Author	Prado, M. Roa, L.M.
Copyright Year	2005
Description	Author affiliation: Escuela Superior de Ingenieros, Seville Univ. (Prado, M.; Roa, L.M.)
Abstract	This paper presents an analysis of different methodologies for modelling pharmacokinetic systems under the context of a telemedicine system oriented to the on-line and personalized knowledge generation. We use a simplified 3-pool kinetic system for a better clarification of several relevant modelling formalisms. A more complete 3-pool urea kinetic model is built simply connecting EL components pertaining to a pharmacokinetic library previously developed. The evolution of the urea concentration during the dialysis of a patient provided by this model was compared successfully to the evolution computed by a 2-pool model experimentally validated. The 3-pool model provides more information regarding the interstice and a high capacity to be modified for attending to the knowledge needs of physicians, as well as biomedicine advances. As a major conclusion, our outcomes suggest that virtual modelling is an excellent methodology in biomedical engineering to support the on-line generation of personalized health knowledge for telemedicine systems. This is due to its capacity for reusing components at horizontal and vertical level, and for implementing multiformalism and multidomain models, what simplifies the task to represent complex physiological and artificial systems
Starting Page	7
Ending Page	10
File Size	246925
Page Count	4
File Format	PDF
ISBN	0780387414
DOI	10.1109/IEMBS.2005.1616328
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-01-17
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biological system modeling Kinetic theory Telemedicine Drugs Humans Computational modeling Joining processes Evolution (biology) Biomedical computing Biomedical engineering
Content Type	Text
Resource Type	Article

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