NDLI: Subcellular effects of nanosecond electrical pulses

Content Provider	IEEE Xplore Digital Library
Author	Schoenbach, K.H. Joshi, R. Kolb, J. Buescher, S. Beebe, S.
Copyright Year	2004
Description	Author affiliation: Center for Bioelectrics, Old Dominion Univ., Norfolk, VA, USA (Schoenbach, K.H.)
Abstract	Electrical models for biological cells predict that reducing the duration of applied electrical pulses to values below the charging time of the outer membrane causes a strong increase in the probability for electric field interactions with intracellular structures. For electric field amplitudes exceeding MV/m such pulses are expected to cause electroporation of cell organelles, with the required electric field amplitude scaling linearly with the inverse of pulse duration. Experimental studies where human cells were exposed to pulsed electric field of up to 300 kV/cm amplitude with duration as short as 10 ns, have confirmed this hypothesis. The observed effects include the breaching of intracellular granule membranes without permanent damage to the cell membrane, abrupt rises in intracellular free calcium levels, and enhanced expression of genes. At increased electric fields, the application of nanosecond pulses induces apoptosis in biological cells, an effect that has been shown to reduce the growth of tumors.
Starting Page	5447
Ending Page	5450
File Size	191163
Page Count	4
File Format	PDF
ISBN	0780384393
DOI	10.1109/IEMBS.2004.1404522
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-09-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Biomembranes Plasma waves Cells (biology) Voltage Plasma properties Nanobioscience Biological cells Calcium Bioelectric phenomena Biology computing nanosecond pulsed electric fields apoptosis calcium release intracellular electro-effects
Content Type	Text
Resource Type	Article

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