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Content Provider | IEEE Xplore Digital Library |
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Author | Wang, L.V. Xueding Wang Geng Ku Xueyi Xie Stoica, G. |
Copyright Year | 2004 |
Description | Author affiliation: Dept. of Biomedical Eng., Texas A&M Univ., College Station, TX, USA (Wang, L.V.; Xueding Wang; Geng Ku; Xueyi Xie; Stoica, G.) |
Abstract | Optical contrast is sensitive to functional parameters, including the oxygen saturation and total concentration of hemoglobin, in biological tissues. However, due to the overwhelming scattering encountered by light in tissues, traditional optical modalities cannot provide satisfactory spatial resolution beyond the ballistic (a few hundred microns) and quasiballistic (1-2 mm) regimes. Photoacoustic tomography is based on the high optical contrast yet utilizing the high ultrasonic resolution. Our work in this emerging area of research will be summarized in this invited talk. In this technology, a diffraction-based inverse-source problem is solved in the image reconstruction, for which we developed the rigorous reconstruction theory. We implemented a prototype and accomplished noninvasive transdermal and transcranial functional imaging of small-animal brains in vivo. Change in the cerebral blood oxygenation of a rat, as a result of the alternation from hyperoxia to hypoxia, was imaged successfully. |
Starting Page | 5307 |
Ending Page | 5310 |
File Size | 410627 |
Page Count | 4 |
File Format | |
ISBN | 0780384393 |
DOI | 10.1109/IEMBS.2004.1404482 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2004-09-01 |
Publisher Place | USA |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Ultrasonic imaging Biophotonics High-resolution imaging Optical scattering Biomedical optical imaging Optical saturation Optical sensors Optical imaging Spatial resolution Image reconstruction oxygen saturation of hemoglobin Photoacoustic tomography optical contrast ultrasonic resolution inverse-source reconstruction |
Content Type | Text |
Resource Type | Article |
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