NDLI: Precise Control of the Drug Kinetics by Non-Invasive Magnetic Drug Delivery System

Content Provider	IEEE Xplore Digital Library
Author	Mishima, F. Nakagawa, K. Chuzawa, M. Mori, T. Akiyama, Y. Nishijima, S.
Copyright Year	2002
Abstract	To solve the problems of side effects and medicinal lowering, studies on the magnetic drug delivery system (MDDS) have been applied. MDDS is a technique to accumulate drugs by using magnetic force as the physical driving force. It is necessary to apply a strong external magnetic field and high magnetic gradient to accumulate the ferromagnetic drugs to a deep diseased part noninvasively. However, by applying a static magnetic field from one direction, the drug accumulates only at the body surface near the magnet. In this study, we proposed a new method of MDDS in which a high-temperature superconducting (HTS) bulk magnet rotates around a target part. First, the particle trajectory simulation was conducted to examine the drug kinetics in a capillary blood vessel under the condition of rotating a magnet. Based on the results, the accumulation experiments of ferromagnetic particles with model blood vessels were conducted. As a result, the accumulation possibility of the ferromagnetic particles in the deep targeted part of the body was confirmed.
Sponsorship	Council on Superconductivity Appl. Superconductivity Conference Inc MIT
Starting Page	4400704
Ending Page	4400704
Page Count	1
File Size	411946
File Format	PDF
ISSN	10518223
Volume Number	23
Issue Number	3
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-06-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Superconducting magnets High temperature superconductors Magnetic fields Magnetic flux Drugs Force Trajectory targeted drug delivery Magnetic forces magnetic particles superconducting magnets
Content Type	Text
Resource Type	Article
Subject	Condensed Matter Physics Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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