NDLI: ß-Tricalcium phosphate/poly(glycerol sebacate) scaffolds with robust mechanical property for bone tissue engineering.

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ß-Tricalcium phosphate/poly(glycerol sebacate) scaffolds with robust mechanical property for bone tissue engineering.

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ß-Tricalcium phosphate/poly(glycerol sebacate) scaffolds with robust mechanical property for bone tissue engineering.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yang, Kai Zhang, Jing Ma, Xiaoyu Ma, Yifan Kan, Chao Ma, Haiyan Li, Yulin Yuan, Yuan Liu, Changsheng
Description	Author Affiliation: Yang K ( The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China); Zhang J ( Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China); Ma X ( Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China); Ma Y ( Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China); Kan C ( Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China); Ma H ( Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.); Li Y ( Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address: yulinli@ecust.edu.cn.); Yuan Y ( The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China); Liu C ( The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, PR China)
Abstract	Despite good biocompatibility and osteoconductivity, porous ß-TCP scaffolds still lack the structural stability and mechanical robustness, which greatly limit their application in the field of bone regeneration. The hybridization of ß-TCP with conventional synthetic biodegradable PLA and PCL only produced a limited toughening effect due to the plasticity of the polymers in nature. In this study, a ß-TCP/poly(glycerol sebacate) scaffold (ß-TCP/PGS) with well interconnected porous structure and robust mechanical property was prepared. Porous ß-TCP scaffold was first prepared with polyurethane sponge as template and then impregnated into PGS pre-polymer solution with moderate viscosity, followed by in situ heat crosslinking and freezing-drying process. The results indicated that the freezing-drying under vacuum process could further facilitate crosslinking of PGS and formation of Ca(2+)-COO(-) ionic complexing and thus synergistically improved the mechanical strength of the ß-TCP/PGS with in situ heat crosslinking. Particularly, the ß-TCP/PGS with 15% PGS content after heat crosslinking at 130°C and freezing-drying at -50°C under vacuum exhibited an elongation at break of 375±25% and a compressive strength of 1.73MPa, 3.7-fold and 200-fold enhancement compared to the ß-TCP, respectively. After the abrupt drop of compressive load, the ß-TCP/PGS scaffolds exhibited a full recovery of their original shape. More importantly, the PGS polymer in the ß-TCP/PGS scaffolds could direct the biomineralization of Ca/P from particulate shape into a nanofiber-interweaved structure. Furthermore, the ß-TCP/PGS scaffolds allowed for cell penetration and proliferation, indicating a good cytobiocompatibility. It is believed that ß-TCP/PGS scaffolds have great potential application in rigid tissue regeneration.
File Format	HTM / HTML
ISSN	09284931
Volume Number	56
e-ISSN	18730191
Journal	Materials Science and Engineering: C
Language	English
Publisher	Elsevier
Publisher Date	2015-11-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Materials Science Bone And Bones Chemistry Calcium Phosphates Decanoates Glycerol Analogs & Derivatives Polymers Tissue Scaffolds Biocompatible Materials Bone Regeneration Calcium Compressive Strength Materials Testing Methods Polyurethanes Tissue Engineering Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject Domain (in MeSH)	Musculoskeletal System Inorganic Chemicals Organic Chemicals Macromolecular Substances Lipids Biomedical and Dental Materials Investigative Techniques Equipment and Supplies Physical Phenomena Musculoskeletal and Neural Physiological Phenomena
Subject	Biomaterials Mechanical Engineering Condensed Matter Physics Mechanics of Materials Bioengineering

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