NDLI: High resolution and high contrast noninvasive photoacoustic imaging of neovascularization in tumor angiogenesis

Content Provider	IEEE Xplore Digital Library
Author	Liangzhong Xiang Da Xing Huaimin Gu Diwu Yang Sihua Yang Lvming Zeng
Copyright Year	2007
Description	Author affiliation: South China Normal Univ., Guangzhou (Liangzhong Xiang; Da Xing; Huaimin Gu; Diwu Yang; Sihua Yang; Lvming Zeng)
Abstract	Photoacoustic tomography (PAT) was presented to in vivo monitor neovascularization in tumor angiogenesis with high resolution and high contrast images in a rat. With a circular scan system, the photoacoustic signal, generated by laser pulses at a wavelength of 532 nm from a Q-switched Nd:YAG laser, is captured through of a hydrophone with a diameter of 1 mm and a sensitivity of 850 nV/Pa. The vascular structure around the rat tumor was imaged clearly, with optimal contrast, because blood has strong absorption near this wavelength. Serial noninvasive photoacoustic images of neovascularization in tumor angiogenesis were also obtained consecutively from a growing tumor implanted under the skin of a rat over a period of two weeks. This work demonstrates that PAT can potentially provide a powerful tool for tumor angiogenesis detection in cancer research. It will bring us closer to clinical application of the technique for tumor diagnosis and treatment monitoring.
Starting Page	979
Ending Page	983
File Size	1694936
Page Count	5
File Format	PDF
ISBN	9781424410774
DOI	10.1109/ICCME.2007.4381886
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-05-23
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	In vivo Image resolution Skin neoplasms High-resolution imaging Sonar equipment Tomography Signal generators Optical pulse generation Signal resolution Monitoring
Content Type	Text
Resource Type	Article

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