NDLI: Study on the Functional Deficit of Brain Cortex in Human Ametropic Amblyopia by fMRI based on Different Task Design Modals

Content Provider	IEEE Xplore Digital Library
Author	Guo Ming-xia Zhang Yun-ting Zhang Quan Li Wei
Copyright Year	2007
Description	Author affiliation: Tianjin Med. Univ., Tianjin (Guo Ming-xia; Zhang Yun-ting)
Abstract	To investigate the functional deficit of brain cortex in human ametropic amblyopia. Methods: The regional brain activation in ametropic amblyopia and healthy subjects evoked by visual stimuli of red-black and green-black chessboard patterns were detected by blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI) based on block-design and event-related design. Results: The major activated brain regions during visual stimulation with block-design modal were in the visual cortex in both ametropic amblyopic and healthy groups; While under the visual stimulation with event-related design modal, the activation were showed in the brain areas that implicated in visual attentional and conscious modulation such as frontal, cingulated, parahippocampal, precentral and temporal regions besides visual fields in both groups. And the intensity of activated areas in ametropic amblyopic group was lower significantly than that in healthy group. Conclusions: The reduced activities of the neurons or reduced synchronization among activity neurons in visual cortex may be major causes of visual cortical deficit in people with ametropic amblyopia. The decreased activation in the regions which related to visual attention and consciousness in ametropic amblyopic group may suggest that the neural network activities among these brain areas and the roles of these areas on visual awareness and cognition in ametropic amblyopic patients become weaker compared to healthy people.
Starting Page	27
Ending Page	30
File Size	657385
Page Count	4
File Format	PDF
ISBN	9781424410774
DOI	10.1109/ICCME.2007.4381685
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-05-23
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain Eyes Hospitals Magnetic resonance imaging Neurons Humans Aging Vision defects Blood Biomedical imaging
Content Type	Text
Resource Type	Article

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