NDLI: Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.

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Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies.

Content Provider	Semantic Scholar
Author	Steen, R. Grant Mull, Courtney McClure, Robert Hamer, Robert M. Lieberman, Jeffrey A.
Copyright Year	2006
Abstract	BACKGROUND Studies of people with schizophrenia assessed using magnetic resonance imaging (MRI) usually include patients with first-episode and chronic disease, yet brain abnormalities may be limited to those with chronic schizophrenia. AIMS To determine whether patients with a first episode of schizophrenia have characteristic brain abnormalities. METHOD Systematic review and meta-analysis of 66 papers comparing brain volume in patients with a first psychotic episode with volume in healthy controls. RESULTS A total of 52 cross-sectional studies included 1424 patients with a first psychotic episode; 16 longitudinal studies included 465 such patients. Meta-analysis suggests that whole brain and hippocampal volume are reduced (both P<0.0001) and that ventricular volume is increased (P<0.0001) in these patients relative to healthy controls. CONCLUSIONS Average volumetric changes are close to the limit of detection by MRI methods. It remains to be determined whether schizophrenia is a neurodegenerative process that begins at about the time of symptom onset, or whether it is better characterised as a neurodevelopmental process that produces abnormal brain volumes at an early age.
File Format	PDF HTM / HTML
DOI	10.1192/bjp.188.6.510
PubMed reference number	16738340
Journal	Medline
Volume Number	188
Alternate Webpage(s)	http://bjp.rcpsych.org/content/bjprcpsych/188/6/510.full.pdf
Alternate Webpage(s)	https://www.cambridge.org/core/services/aop-cambridge-core/content/view/F118CD7459D1E1A0F741BB4A216CFC58/S0007125000231875a.pdf/brain_volume_in_firstepisode_schizophrenia.pdf
Alternate Webpage(s)	https://doi.org/10.1192/bjp.188.6.510
Journal	The British journal of psychiatry : the journal of mental science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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