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Thermal ablation by high-intensity-focused ultrasound using a toroidal transducer for the treatment of colorectal liver metastases during an open procedure. Clinical results
Content Provider | Semantic Scholar |
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Author | Melodelima, David Vincenot, Jérémy Dupré, A. Chen, Y. Gandini, Alessandro Rivoire, Michel |
Copyright Year | 2013 |
Abstract | The objective of this clinical study was to validate the effectiveness, accuracy, tolerance and safety of a HIFU treatment developed for the treatment of liver metastases. Fifteen patients were included. The transducer has a toroidal shape (diameter: 70 mm, radius of curvature: 70 mm) and was divided into 256 ultrasound emitters operating at 3 MHz. A 7.5 MHz ultrasound imaging probe was placed in the centre of the device. All HIFU ablations were obtained in 40 seconds. The demarcation between ablated and non-ablated tissue was clearly apparent in ultrasound images and histology. In Phase I (6 patients) we demonstrated that the dimensions of HIFU ablations measured on ultrasound imaging were correlated (r=0.88) with dimensions measured during histological analysis. The average dimensions obtained from each HIFU ablation were a diameter of 21.0 ± 3.9 mm and a depth of 27.5 ± 6.0 mm. In Phase II (9 patients), the HIFU ablations were centered on a target previously identified with a precision of 1-2 mm. It wa... |
Starting Page | 75063 |
Ending Page | 75063 |
Page Count | 1 |
File Format | PDF HTM / HTML |
DOI | 10.1121/1.4805953 |
Volume Number | 133 |
Language | English |
Access Restriction | Open |
Content Type | Text |
Resource Type | Article |