NDLI: A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases

Please wait, while we are loading the content...

A Survey of Gene Prioritization Tools for Mendelian and Complex Human Diseases

Content Provider	Scilit
Author	Zolotareva, Olga Kleine, Maren
Copyright Year	2019
Description	Modern high-throughput experiments provide us with numerous potential associations between genes and diseases. Experimental validation of all the discovered associations, let alone all the possible interactions between them, is time-consuming and expensive. To facilitate the discovery of causative genes, various approaches for prioritization of genes according to their relevance for a given disease have been developed. In this article, we explain the gene prioritization problem and provide an overview of computational tools for gene prioritization. Among about a hundred of published gene prioritization tools, we select and briefly describe 14 most up-to-date and user-friendly. Also, we discuss the advantages and disadvantages of existing tools, challenges of their validation, and the directions for future research.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074139/pdf http://www.degruyter.com/downloadpdf/j/jib.ahead-of-print/jib-2018-0069/jib-2018-0069.xml
e-ISSN	16134516
DOI	10.1515/jib-2018-0069
Journal	Journal of Integrative Bioinformatics
Issue Number	4
Volume Number	16
Language	English
Publisher	Walter de Gruyter GmbH
Publisher Date	2019-09-09
Access Restriction	Open
Subject Keyword	Journal of Integrative Bioinformatics Genetics Data Integration; Gene Prioritization; Human Diseases Journal: Journal of Integrative Bioinformatics, Vol- 16
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in