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Postprandial incorporation of EPA and DHA from transgenic Camelina sativa oil into blood lipids is equivalent to that from fish oil in healthy humans
| Content Provider | Scilit |
|---|---|
| Author | West, Annette L. Miles, Elizabeth A. Lillycrop, Karen A. Han, Lihua Sayanova, Olga Napier, Johnathan A. Calder, Philip C. Burdge, Graham C. |
| Copyright Year | 2019 |
| Description | EPA and DHA are important components of cell membranes. Since humans have limited ability for EPA and DHA synthesis, these must be obtained from the diet, primarily from oily fish. Dietary EPA and DHA intakes are constrained by the size of fish stocks and by food choice. Seed oil from transgenic plants that synthesise EPA and DHA represents a potential alternative source of these fatty acids, but this has not been tested in humans. We hypothesised that incorporation of EPA and DHA into blood lipids from transgenicCamelina sativaseed oil (CSO) is equivalent to that from fish oil. Healthy men and women (18–30 years or 50–65 years) consumed 450 mg EPA + DHA from either CSO or commercial blended fish oil (BFO) in test meals in a double-blind, postprandial cross-over trial. There were no significant differences between test oils or sexes in EPA and DHA incorporation into plasma TAG, phosphatidylcholine or NEFA over 8 h. There were no significant differences between test oils, age groups or sexes in postprandial VLDL, LDL or HDL sizes or concentrations. There were no significant differences between test oils in postprandial plasma TNFα, IL 6 or 10, or soluble intercellular cell adhesion molecule-1 concentrations in younger participants. These findings show that incorporation into blood lipids of EPA and DHA consumed as CSO was equivalent to BFO and that such transgenic plant oils are a suitable dietary source of EPA and DHA in humans. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658215/pdf https://www.cambridge.org/core/services/aop-cambridge-core/content/view/15260D4F130BE0BCC2F6AA86359F0A34/S0007114519000825a.pdf/div-class-title-postprandial-incorporation-of-epa-and-dha-from-transgenic-span-class-italic-camelina-sativa-span-oil-into-blood-lipids-is-equivalent-to-that-from-fish-oil-in-healthy-humans-div.pdf |
| Ending Page | 1246 |
| Page Count | 12 |
| Starting Page | 1235 |
| ISSN | 00071145 |
| e-ISSN | 14752662 |
| DOI | 10.1017/s0007114519000825 |
| Journal | British Journal Of Nutrition |
| Issue Number | 11 |
| Volume Number | 121 |
| Language | English |
| Publisher | Cambridge University Press (CUP) |
| Publisher Date | 2019-04-12 |
| Access Restriction | Open |
| Subject Keyword | British Journal Of Nutrition Transgenic Plants Postprandial Metabolism Camelina Sativa Seed Oil Fatty Acid Methyl Esters Incremental Area Under the Time × Concentration Curve Phosphatidylcholine Soluble Intercellular Cell Adhesion Molecule |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nutrition and Dietetics Medicine |
