NDLI: G protein-gated I KACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

Content Provider	PubMed Central
Author	Mesirca, Pietro Bidaud, Isabelle François, Briec Evain, Stéphane Torrente, Angelo G. Quang, Khai Le Leoni, Anne-laure Baudot, Matthias Laurine, Marger Chong, Antony Chung You Nargeot, Joël Joerg, Striessnig Wickman, Kevin Charpentier, Flavien Mangoni, Matteo E.
Abstract	The “sick sinus” syndrome (SSS) is characterized by abnormal formation and/or propagation of the cardiac impulse. SSS is responsible for about half of the total implantations of electronic pacemakers, which constitute the only currently available therapy for this disorder. We show that genetic ablation or pharmacological inhibition of the muscarinic-gated K+ channel (I KACh ) prevents SSS and abolishes atrioventricular block in model mice without affecting the relative degree of heart rate regulation. We propose that “compensatory” genetic or pharmacological targeting of I KACh channels may constitute a new paradigm for restoring defects in the balance between inward and outward currents in pacemaker cells. Our study may thus open a new therapeutic perspective to manage dysfunction of formation and conduction of the cardiac impulse.
Related Links	http://dx.doi.org/10.1073/pnas.1517181113
Starting Page	932
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	113
Language	English
Publisher	National Academy of Sciences
Publisher Date	2016-02-16
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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G protein-gated $I_{KACh}$ channels as therapeutic targets for treatment of sick sinus syndrome and heart block

G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

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G protein-gated I KACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block

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