NDLI: Nanosecond pulsed electric fields: Microdosimetry on single cells

Content Provider	IEEE Xplore Digital Library
Author	Merla, C. Paffi, A. Liberti, M. Apollonio, F. Danei, F. Leveque, P. d'Inzeo, G.
Copyright Year	2010
Description	Author affiliation: XLIM, CNRS-University of Limoges 123 Av. Albert Thomas, 87060 Limoges cedex, France (Leveque, P.) \|\| ICEmB at “Sapienza” University of Rome, via Eudossiana 18, 00184 Rome, Italy (Merla, C.; Paffi, A.; Liberti, M.; Apollonio, F.; Danei, F.; d'Inzeo, G.)
Abstract	A microdosimetric study on nanosecond pulsed electric fields (nsPEF) including cell compartments dispersivity through Debye equation has been detailed in this paper. A quasi-static solution properly adapted for a wide band analysis and coupled with an asymptotic electroporation model has been used to face the problem. Main paper results highlight the relevance of Debye modeling for nsPEF microdosimetry, evidencing that both the trans-membrane potential (TMP) and the pore density are strongly influenced by such a modeling choice. Particularly, an electric (E) field variability up to 70 % has been observed during the pulse rise time, when the high frequency components of the nsPEF prevail, inducing consequently strong pore density alterations within the cell membrane. Furthermore the influence of the use of different membrane dielectric models has been analyzed. The presented results have demonstrated the crucial role of the dielectric membrane characteristics and the importance of their accurate and reliable determination.
Starting Page	1
Ending Page	3
File Size	320868
Page Count	3
File Format	PDF
ISBN	9781424464319
e-ISBN	9788476534724
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-04-12
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	EurAAP
Subject Keyword	Coupled mode analysis Cells (biology) Frequency Biomembranes Dielectrics Plasmas Performance analysis Nanobioscience Equations Wideband
Content Type	Text
Resource Type	Article

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