NDLI: Next-Generation Bioimaging Systems

Content Provider	IEEE Xplore Digital Library
Author	Kovacevic, J.
Copyright Year	2006
Description	Author affiliation: Dept. of Biomed. Eng., Carnegie Mellon Univ., Pittsburgh, PA (Kovacevic, J.)
Abstract	The question I would like to help answer is: What is the role and what can imaging do for systems biology? In recent years, the focus in biological sciences has shifted from understanding single parts of larger systems, sort of vertical approach, to understanding complex systems at the cellular and molecular levels, horizontal approach. Thus the revolution of "omics" projects, genomics and now proteomics. Understanding complexity of biological systems is a task that requires acquisition, analysis and sharing of huge databases, and in particular, high-dimensional databases. For example, in the current project on location proteomics, the fluorescence microscopy data sets can have a dimension as high as 5: two spatial dimensions, z-stacks, time series and different-color channels (different color probes for different proteins). Processing such huge amount of bioimages visually by biologists is inefficient, time-consuming and error-prone. Therefore, we would like to move towards automated, efficient and robust processing of such bioimage data sets. Moreover, some information hidden in the images may not be readily visually available. For example, in the same project, we use images of two proteins residing in the Golgi apparatus-giantin and gpp130. These two proteins cannot be distinguished better than randomly by humans, while when employing data mining methods, they can be told apart. Therefore, we do not only replace humans by machines for faster and more efficient processing but also because new knowledge is generated through use of sophisticated algorithms. The ultimate dream is to have distributed yet integrated large bioimage databases which would allow researchers to upload their data, have it processed, share the data, download data as well as platform-optimized code, etc., and all this in a common format, something akin to the DICOM format for clinical imaging. To achieve this goal, we must draw upon a whole host of sophisticated tools from signal processing, machine learning and scientific computing. While such tools are widely present in clinical (medical) imaging, they are not as widespread in imaging of biological systems at cellular and molecular levels. This is a huge challenge and requires integration of interdisciplinary teams. I will address some of these issues in this presentation
Starting Page	1
Ending Page	1
File Size	1285282
Page Count	1
File Format	PDF
ISBN	1424404126
DOI	10.1109/NORSIG.2006.275271
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-06-07
Publisher Place	Iceland
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Systems biology Humans Focusing Proteomics Biological systems Spatial databases Visual databases Biological information theory Bioinformatics
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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