NDLI: Contrast-enhanced ultrasound imaging for the detection of transient dynamics of blood-brain barrier opening induced by focused ultrasound

Content Provider	IEEE Xplore Digital Library
Author	Chien-Yu Ting Ching-Hsiang Fan Wun-Hao Lin Wen-Yen Chai Hao-Li Liu Tzu-Chen Yen Chih-Kuang Yeh
Copyright Year	2013
Description	Author affiliation: Dept. of Biomed. Eng. & Environ. Sci., Nat. Tsing Hua Univ., Hsinchu, Taiwan (Chien-Yu Ting; Ching-Hsiang Fan; Wun-Hao Lin; Chih-Kuang Yeh) \|\| Dept. of Nucl. Med., Chang Gung Univ., Gueishan, Taiwan (Tzu-Chen Yen) \|\| Dept. of Electr. Eng., Chang-Gung Univ., Gueishan, Taiwan (Wen-Yen Chai; Hao-Li Liu)
Abstract	Focused ultrasound (FUS) in the presence of circulating microbubbles (MBs) has been confirmed to temporarily and locally enhance the permeability of the blood-brain barrier (BBB). However, improper FUS sonication parameters not only achieve BBB destruction (BBBD) but also induce brain damages such as intracerebral hemorrhage (ICH), brain edema, transient blood-supply shortage. Therefore, it is essential to develop a real-time imaging system to assess the dynamic perfusion changes during FUS-induced BBBD process. Here, we proposed a high-frequency microultrasound imaging system with sigmoid-based destruction and replenishment (D/R) technique for the observation of brain microcirculation changes after performing BBBD with or without hemorrhage. The BBB was disrupted by a 2.25-MHz FUS probe with acoustic pressure of 0.5 MPa and 0.7 MPa (for without and with hemorrhage group, respectively), pulse repetition frequency of 1 Hz, pulse length of 1 ms, and sonication duration of 60 s following intravenous injection of MBs. The results showed that the velocity of blood flow decreased after BBBD. The location of slowing down of the local flow velocity was consistent with the BBBD area and also the local enhanced permeability region detected by MR Ktrans imaging. In addition, the variation of blood flow depended on the applied acoustic pressure, and the position where flow velocity became particularly slow was associated with the occurrence of hemorrhage. In conclusion, our proposed ultrasound D/R imaging technique provides a useful tool for monitoring both the region and degree of BBBD and the presence of hemorrhage during BBBD process. This novel method provides an immediate feedback for the control of BBBD and avoiding or minimizing bioeffect in the future.
Sponsorship	IEEE Ultrason., Ferroelectr., Freq. Control Society
Starting Page	2088
Ending Page	2091
File Size	11586513
Page Count	4
File Format	PDF
ISSN	19485719
e-ISBN	9781467356862
DOI	10.1109/ULTSYM.2013.0533
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-21
Publisher Place	Czech Republic
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Permeability Hemorrhaging Blood flow Magnetic resonance imaging Transducers destruction/replenishment Blood-brain barrier microbubbles focused ultrasound
Content Type	Text
Resource Type	Article

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