NDLI: Observation of rat brain tumor model and its quantitative analysis by acoustic impedance microscopy

Content Provider	IEEE Xplore Digital Library
Author	Hozumi, N. Yoshida, S. Kobayashi, K. Saijo, Y. Miura, K. Yamamoto, S.
Copyright Year	2012
Description	Author affiliation: Honda Electron. Co., Ltd., Toyohashi, Japan (Kobayashi, K.) \|\| Tohoku Univ., Sendai, Japan (Saijo, Y.) \|\| Sch. of Med., Hamamatsu Univ., Hamamatsu, Japan (Miura, K.; Yamamoto, S.) \|\| Toyohashi Univ. of Technol., Toyohashi, Japan (Hozumi, N.; Yoshida, S.)
Abstract	Glioma is known with its strong invasion. As there is a limitation in preoperative inspection, the only procedure for improving postoperative result is to examine, during the operation, if there is no residual tumor, and if any, to remove as completely as possible. For this purpose, a quick and compact observation tool with a high contrast and spatial resolution is required. Acoustic micro-imaging for biological tissues can be performed quickly without staining process. This study is aimed for establishing in situ detection for brain tumor during surgery. Under general anesthesia, rats were received with an intracerebral injection of C6 glioma cells. The brain was taken out and its coronal section was exposed 14 days later. The cross section was placed on a polypropylene substrate, and was observed by transmitting an ultrasound from the other side of the substrate. The ultrasound, of which central frequency was ca. 80 MHz, was focused on the interface between the substrate and tissue. The reflection, received by the identical transducer, was interpreted into the local characteristic acoustic impedance (CAI) of the tissue. By scanning the transducer, a cross sectional CAI profile was obtained. The morphological inspection of the CAI profile allowed us to identify the tumor. The average value of CAI in tumor region did not significantly differ from that in the normal region. However, the tumor region showed considerable heterogeneity in the CAI pattern. Standard deviation of CAI in a small probing area was defined as the local heterogeneity. The heterogeneity profile, which was obtained by scanning the probing area, successfully highlighted the tumor region.
Starting Page	2372
Ending Page	2375
File Size	976833
Page Count	4
File Format	PDF
ISBN	9781467345613
ISSN	19485719
e-ISBN	9781467345620
DOI	10.1109/ULTSYM.2012.0593
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-07
Publisher Place	Germany
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Acoustics Tumors Computer aided instruction Impedance Substrates Microscopy Optical imaging tissue characterization acoustic microscope glioma
Content Type	Text
Resource Type	Article

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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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