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Content Provider | IEEE Xplore Digital Library |
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Author | Chien-Yu Ting Ching-Hsiang Fan Hao-Li Liu Tzu-Chen Yen Kuo-Chen Wei Chih-Kuang Yeh |
Copyright Year | 2011 |
Description | Author affiliation: Dept. of Electr. Eng., Chang-Gung Univ., Taoyuan, Taiwan (Hao-Li Liu) || Dept. of Neurosurg., Chang Gung Univ., Taoyuan, Taiwan (Kuo-Chen Wei) || Dept. of Nucl. Med., Chang Gung Univ., Taoyuan, Taiwan (Tzu-Chen Yen) || Dept. of Biomed. Eng. & Environ. Sci., Nat. Tsing Hua Univ., Hsinchu, Taiwan (Chien-Yu Ting; Ching-Hsiang Fan; Chih-Kuang Yeh) |
Abstract | Glioblastoma multiforme (GBM) is a highly malignant brain tumor. The blood-brain barrier (BBB) provides a major obstacle to chemotherapy since therapeutic doses cannot be achieved by traditional drug delivery without severe systemic cytotoxic effects. Recently, microbubble (MB)-enhanced focused ultrasound (FUS) was shown to temporally and locally disrupt the BBB thereby enhancing drug delivery into brain tumors. Here we propose the concept of smart, multifunctional MBs capable of facilitating FUS-induced BBB disruption while serving as drug carrying vehicles and protecting drugs from rapid degradation. The designed MBs had a high loading capacity (efficiency of 68.01 ± 4.35 %) for 1,3-bis(2-chloroethyl)-1- nitrosourea (BCNU). When combined with FUS (1-MHz), these BCNU-MBs facilitated local BBB disruption and simultaneously released BCNU at the target site, thus increasing local BCNU deposition. And accumulation of BCNU in the liver was reduced 5-fold due to the slow reticuloendothelial system uptake of BCNU-MBs. In tumor-bearing animals, BCNU-MBs with FUS controlled tumor progression (915.3 % to 39.6 %) and improved median survival (29 days to 32.5 days). This study provides a new approach for designing multifunctional MBs to facilitate FUS-mediated chemotherapy for brain tumor treatment. |
Sponsorship | IEEE Ultrasonics, Ferroelectrics Frequency Control Soc. |
Starting Page | 1463 |
Ending Page | 1466 |
File Size | 621964 |
Page Count | 4 |
File Format | |
ISBN | 9781457712531 |
ISSN | 19485727 |
e-ISBN | 9781457712524 |
DOI | 10.1109/ULTSYM.2011.6293471 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2011-10-18 |
Publisher Place | USA |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Tumors Drugs Liver Animals Ultrasonic imaging Acoustics Brain blood-brain barrier (BBB) glioblastoma multiforme (GBM) focused ultrasound (FUS) microbubble (MB) chemotherapy |
Content Type | Text |
Resource Type | Article |
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