NDLI: Comparison of ultrasound scattering properties of Optison(R) with a liquid perfluorocarbon nanoparticle contrast agent

Content Provider	IEEE Xplore Digital Library
Author	Hughes, M.S. Marsh, J.N. Fuhrhop, R.W. Chinen, L.K. Lanza, G.M. Wickline, S.A.
Copyright Year	2001
Description	Author affiliation: Cardiovascular Div., Washington Univ. Sch. of Med., St. Louis, MO, USA (Hughes, M.S.)
Abstract	Previously we reported that useful ultrasound contrast enhancement could be obtained using a liquid emulsion contrast agent developed in our laboratory. The physical basis for this enhancement was unknown at the time of our report, although the effect was reproducible, in vivo and in vitro. We hypothesize that microbubble formation does not play a significant role in the acoustic behavior of these contrast agents, otherwise attenuation and backscatter would be. significantly affected by changes in hydrostatic pressure, acoustic pressure, and show evidence of scattering agent destruction as the duration of ultrasound exposure increased. Measurements of attenuation coefficient and backscatter of Optison and the emulsion were made in a water bath maintained at temperatures ranging from 37/spl deg/ to 50/spl deg/C. The emulsion nanoparticles were produced by methods standard in our laboratory using perfluorooctyl bromide (PFOB: boiling point 142/spl deg/C) or perfluorooctane (PFO: boiling point 99/spl deg/C) as the major component. Particle size was measured at 435 and 375 /spl plusmn/ 30 nm respectively. We varied ambient hydrostatic pressure (-50 to 200 mm Hg in 50 mm steps), duration of exposure to insonifying acoustic field (2, 20, 40, 80 s), peak positive and negative acoustic pressure (0.038 to 3.0 MPa).
Sponsorship	Ultrasonics, Ferroelectr., & Frequency Control Soc
Starting Page	1675
Ending Page	1678
File Size	337851
Page Count	4
File Format	PDF
ISBN	0780371771
DOI	10.1109/ULTSYM.2001.992043
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2001-10-07
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Acoustic scattering Particle scattering Laboratories Backscatter Acoustic measurements In vivo In vitro Attenuation measurement Ultrasonic variables measurement
Content Type	Text
Resource Type	Article

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