NDLI: Microbubbles during tissue treatment using high intensity focused ultrasound

Content Provider	IEEE Xplore Digital Library
Author	Sanghvi, N.T. Fry, F.J. Bihrle, R. Foster, R.S. Phillips, M.H. Syrus, J. Zaitsev, A. Hennige, C.
Copyright Year	1995
Description	Author affiliation: Indianapolis Center for Adv. Res. Inc., IN, USA (Sanghvi, N.T.)
Abstract	Based on our previous animal experiments in the treatment of dog prostates and data from others, we selected HIFU parameters, (i.e. focal intensity, Isptp/spl ap/1680 W/cm/sup 2/, frequency 4 MHz and treatment exposure time=4 On/12 Off sec.), to produce thermally induced focal lesions. Using the same acoustic parameters, patient treatment for the benign prostatic hyperplasia (BPH) was commenced in 1992. During the treatment, in some patients, microbubble initiation at the focal site was observed. These microbubbles migrated towards the ultrasound near field as the HIFU procedure continued. To elucidate the similar response, animal experiments were carried out. This paper describes initiation of microbubbles at the focal site followed by their proliferation in the dog prostate during the treatment and finally their effects on tissue lesions. The microbubbles were observed by ultrasound imaging and monitored by subharmonics and broadband signals on the frequency spectrum analyzer. The temperature at the rectal wall was measured to observe and follow the effects of microbubbles in-vivo.
Starting Page	1571
Ending Page	1574
File Size	228701
Page Count	4
File Format	PDF
ISBN	0780329406
ISSN	10510117
DOI	10.1109/ULTSYM.1995.495855
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1995-11-07
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Animals Frequency Lesions Medical treatment Focusing Monitoring Spectral analysis Temperature Ultrasonic variables measurement
Content Type	Text
Resource Type	Article

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