NDLI: PET quantification inaccuracy of non-uniform tracer distributions for radiation therapy

Content Provider	IEEE Xplore Digital Library
Author	Kirov, A.S. Danford, C. Schmidtlein, C.R. Yorke, E. Hurnm, J.L. Amols, H.I.
Copyright Year	2007
Description	Author affiliation: Memorial Sloan-Kettering Cancer Center, New York (Kirov, A.S.; Danford, C.; Schmidtlein, C.R.; Yorke, E.; Hurnm, J.L.; Amols, H.I.)
Abstract	The quantitative accuracy of PET has been measured for phantoms containing uniform activity spheres and cylinders, but has never been studied for non-uniformly varying tracer concentration (TC) distributions. For the correct delineation of tumors for radiation therapy (RT) using PET, the combined effect of all PET image degrading factors for realistic cases needs to be known. We investigate PET inaccuracy for a phantom with TC and attenuation varying non-uniformly in one direction. This ID model enables determination of the positional, angular and statistical effects on the quantification accuracy. We simulated a cylindrical uniform TC phantom containing a non-uniform TC insert using the GATE (Geant4 Application for Tomographic Emission) Monte Carlo code. The insert is made of thin parallel slabs with different TC, atomic composition and density. The phantom is simulated inside a validated model of the GE Discovery LS PET/CT scanner. The Software for Tomographic Image Reconstruction (STIR) was used to reconstruct the PET images, which were then analyzed by comparing the reconstructed to true TC recovery coefficients. Simulated images with and without attenuation (AC) and scatter and random events included and rejected were analyzed. The results showed that for strongly non-uniform attenuation and adequate statistics, very accurate attenuation, scatter and random corrections are needed to achieve accuracy better than 20% for most voxels, except close to regions with high gradient, where larger differences are seen. Insufficient scatter and random corrections lead to underestimation of the TC in regions with low attenuation. In such cases, tumors in the lung and close to the end of the axial FOV and with low statistics may not be seen. Reliable estimates of the quantification inaccuracy of 3D PET are needed if 3D PET is to be used for tumor segmentation and dose painting for radiation therapy.
Starting Page	2838
Ending Page	2841
File Size	691990
Page Count	4
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4436727
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Biomedical applications of radiation Attenuation Imaging phantoms Image reconstruction Scattering Neoplasms Image analysis Statistics Degradation
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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