NDLI: Design and fabrication of multi-microelectrode array with SAMs surface modification for neural prosthesis

Content Provider	IEEE Xplore Digital Library
Author	Cheng-Hung Chang Jia-Jin Jason Chen Jiunn-Der Liao
Copyright Year	2004
Abstract	Neural prostheses are devices that utilize electrical stimulation or recording technique to activate the damaged or disabled nervous system for function restoration. Among varied electrodes, nerve cuff electrodes have been used for neuroprosthetic applications in peripheral nerve system. However, an increase in electrode impedance might occur during clinical implantation. Our research was in an attempt to minimize the protein absorption and elongate life of the implantable nerve cuff electrode by using the self-assembled monolayer (SAMs) surface modification technique. In this work, a thin-film SAMs treatment upon Au/polyimide surface of the microelectrode provided a hydrophobic characteristic, which retarded proteins adsorption at the initial stage and subsequent pile-up process. Gold electrode treated by SAMs film permits the control of interactions of the biomolecule-electrode surface at the molecular scale. A novel design multi-polar spiral cuff electrode, composed of SAMs treated gold electrodes and flexible polyimide substrate, was fabricated and evaluated.
Starting Page	246
Ending Page	247
File Size	231842
Page Count	2
File Format	PDF
ISBN	4990247205
DOI	10.1109/IMNC.2004.245819
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-10-26
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Japan Soc. of Applied, Phys.
Subject Keyword	Fabrication Prosthetics Electrodes Proteins Surface treatment Gold Microelectrodes Biomedical engineering Surface impedance Polyimides
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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