NDLI: Integrative control of respiration in the sleep apnea syndrome

Content Provider	IEEE Xplore Digital Library
Author	Remmers, J.E. Topor, Z. Poulin, M.
Copyright Year	2002
Description	Author affiliation: Dept. of Physiol. & Biophys., Calgary Univ., Alta., Canada (Remmers, J.E.)
Abstract	Spontaneous pulmonary ventilation is a remarkably well-controlled process in mammals. Humans, however, may experience disturbance of ventilatory control during sleep owing to narrowing of their collapsible pharynx or alterations in the gain of the chemoreflex feedback loops. Consequently, during sleep, some fail to generate stable breathing with a level of alveolar ventilation that is appropriate for metabolic needs. Such disturbances result either from a mechanical load on the pump muscles caused by narrowing of the pharyngeal airway or from unstable chemoreflex control. The former is referred to as obstructive sleep-disordered breathing and the latter as central sleep-disordered breathing. While this dichotomous conceptualization describes severe examples of sleep-disordered breathing, current evidence suggests that both types of pathophysiologic processes co-exist, with the ultimate expression of ventilatory pattern being the outcome of a complex interplay between the obstructive and central pathophysiological processes. The article looks at this interplay to see how integrative respiration control is achieved.
Starting Page	1501
Ending Page	1503
File Size	198134
Page Count	3
File Format	PDF
ISBN	0780376129
ISSN	1094687X
DOI	10.1109/IEMBS.2002.1106505
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-10-23
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sleep apnea Ventilation Muscles Pharynx Delay Control systems Brain Centralized control Humans Feedback loop
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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