NDLI: An equivalent current source model and Laplacian weighted minimum norm current estimates of brain electrical activity

Content Provider	IEEE Xplore Digital Library
Author	Bin He Yao, D. Lian, J. Wu, D.
Copyright Year	1964
Abstract	We have developed a method for estimating the three-dimensional distribution of equivalent current sources inside the brain from scalp potentials. Laplacian weighted minimum norm algorithm has been used in the present study to estimate the inverse solutions. A three-concentric-sphere inhomogeneous head model was used to represent the head volume conductor. A closed-form solution of the electrical potential over the scalp and inside the brain due to a point current source was developed for the three-concentric-sphere inhomogeneous head model. Computer simulation studies were conducted to validate the proposed equivalent current source imaging. Assuming source configurations as either multiple dipoles or point current sources/sinks, in computer simulations we used our method to reconstruct these sources, and compared with the equivalent dipole source imaging. Human experimental studies were also conducted and the equivalent current source imaging was performed on the visual evoked potential data. These results highlight the advantages of the equivalent current source imaging and suggest that it may become an alternative approach to imaging spatially distributed current sources-sinks in the brain and other organ systems.
Sponsorship	IEEE Engineering in Medicine and Biology Society
Page Count	12
File Size	540074
Starting Page	277
Ending Page	288
File Format	PDF
ISSN	00189294
Volume Number	49
Issue Number	4
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-04-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain modeling Laplace equations Head Scalp Computer simulation Conductors Closed-form solution Electric potential Image reconstruction Humans
Content Type	Text
Resource Type	Article
Subject	Biomedical Engineering

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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