NDLI: Lesion detectability and quantification in PET/CT oncological studies by Monte Carlo simulations

Content Provider	IEEE Xplore Digital Library
Author	Castiglioni, I. Rizzo, G. Gilardi, M.C. Bettinardi, V. Savi, A. Fazio, F.
Copyright Year	1963
Abstract	The aim of this work was to assess lesion detectability and quantification in whole body oncological /sup 18/F-FDG studies performed by a state-of-the-art integrated Positron Emission Tomograph/computed tomography (PET/CT) system. Lesion detectability and quantification were assessed by a Monte Carlo (MC) simulation approach as a function of different physical factors (e.g., attenuation and scatter), image counting statistics, lesion size and position, lesion-to-background radioactivity concentration ratio (L/B), and reconstruction algorithms. The results of this work brought to a number of conclusions. The MC code PET-electron gamma shower (EGS) was accurate in simulating the physical response of the considered PET/CT scanner (>90%). PET-EGS and patient-derived phantoms can be used in simulating/sup 18/ F-FDG PET oncological studies. Counting statistics is a dominant factor in lesion detectability. Correction for scatter (from both inside and outside the field of view) is needed to improve lesion detectability. Iterative reconstruction and attenuation correction must be used to interpret clinical images. Re-binning algorithms are appropriate for whole-body oncological data. A MC-based method for correction of partial volume effect is feasible. For the considered PET/CT system, limits in lesion detectability were determined in situations comparable to those of real oncological studies: at a L/B=3 for lesions of 12 mm diameter and at a L/B=4 for lesions of 8 mm diameter.
Sponsorship	IEEE Nuclear and Plasma Sciences Society Computer Applications in Nuclear and Plasma Sciences (CANPS) Lawrence Berkeley Lab. Lawrence Livermore Nat. Lab. APS College of William and Mary Continuous Electron Beam Accelerator Facility NASA Defence Nuclear Agency Sandia National Laboratories Jet Propulsion Laboratory Brookhaven Nat. Lab. Lawrence Livermore Nat. Lab IEEE/NPPS Radiat. Effects Committee Defence Nuclear Agency/DoD Sandia National Laboratories/DOE Jet Propulsion Laboratory/NASA Phillips Lab./DoD
Starting Page	136
Ending Page	142
Page Count	7
File Size	1752597
File Format	PDF
ISSN	00189499
Volume Number	52
Issue Number	1
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-02-01
Publisher Place	U.S.A.
Access Restriction	One Nation One Subscription (ONOS)
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lesions Positron emission tomography Computed tomography Whole-body PET Attenuation Scattering Statistics Radioactive decay Monte Carlo methods Computational modeling PET/CT Lesion detectability Monte Carlo
Content Type	Text
Resource Type	Article
Subject	Nuclear and High Energy Physics Electrical and Electronic Engineering Nuclear Energy and Engineering

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