NDLI: Characterization of the Discrepancies Between Four-Dimensional Phase-Contrast Magnetic Resonance Imaging and In-Silico Simulations of Cerebrospinal Fluid Dynamics

Content Provider	The American Society of Mechanical Engineers (ASME) Digital Collection
Author	Pahlavian, Soroush Heidari Bunck, Alexander C. Loth, Francis Tubbs, R. Shane Yiallourou, Theresia Kroeger, Jan Robert Heindel, Walter Martin, Bryn A.
Copyright Year	2015
Abstract	The purpose of the present study was to compare subject-specific magnetic resonance imaging (MRI)-based computational fluid dynamics (CFD) simulations with time-resolved three-directional (3D) velocity-encoded phase-contrast MRI (4D PCMRI) measurements of the cerebrospinal fluid (CSF) velocity field in the cervical spinal subarachnoid space (SSS). Three-dimensional models of the cervical SSS were constructed based on MRI image segmentation and anatomical measurements for a healthy subject and patient with Chiari I malformation. CFD was used to simulate the CSF motion and compared to the 4D PCMRI measurements. Four-dimensional PCMRI measurements had much greater CSF velocities compared to CFD simulations (1.4 to 5.6× greater). Four-dimensional PCMRI and CFD both showed anterior and anterolateral dominance of CSF velocities, although this flow feature was more pronounced in 4D PCMRI measurements compared to CFD. CSF flow jets were present near the nerve rootlets and denticulate ligaments (NRDL) in the CFD simulation. Flow jets were visible in the 4D PCMRI measurements, although they were not clearly attributable to nerve rootlets. Inclusion of spinal cord NRDL in the cervical SSS does not fully explain the differences between velocities obtained from 4D PCMRI measurements and CFD simulations.
Starting Page	051002
Ending Page	051008
Page Count	7
File Format	PDF
ISSN	01480731
e-ISSN	15288951
Journal	Journal of Biomechanical Engineering
Volume Number	137
Issue Number	5
DOI	10.1115/1.4029699
Language	English
Publisher	The American Society of Mechanical Engineers
Publisher Date	2015-05-01
Access Restriction	Subscribed
Subject Keyword	Computational fluid dynamics Flow (Dynamics) Magnetic resonance imaging Simulation
Content Type	Text
Resource Type	Article
Subject	Physiology (medical) Biomedical Engineering

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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