NDLI: Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1996 Volume: 93 Issue: 26

Year: 1996 Volume: 93 Issue: 25

Year: 1996 Volume: 93 Issue: 24

Year: 1996 Volume: 93 Issue: 23

Year: 1996 Volume: 93 Issue: 22

Year: 1996 Volume: 93 Issue: 21

Year: 1996 Volume: 93 Issue: 20

Year: 1996 Volume: 93 Issue: 19

Year: 1996 Volume: 93 Issue: 18

Year: 1996 Volume: 93 Issue: 17

Year: 1996 Volume: 93 Issue: 16

Year: 1996 Volume: 93 Issue: 15

Year: 1996 Volume: 93 Issue: 14

Year: 1996 Volume: 93 Issue: 13

Year: 1996 Volume: 93 Issue: 12

Year: 1996 Volume: 93 Issue: 11

Year: 1996 Volume: 93 Issue: 10

Year: 1996 Volume: 93 Issue: 9

Year: 1996 Volume: 93 Issue: 8

Year: 1996 Volume: 93 Issue: 7

Year: 1996 Volume: 93 Issue: 6

Year: 1996 Volume: 93 Issue: 5

Year: 1996 Volume: 93 Issue: 4

Year: 1996 Volume: 93 Issue: 3

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

Compressibility as a means to detect and characterize globular protein states.

Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements.

Structural changes of tumor necrosis factor alpha associated with membrane insertion and channel formation.

Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts.

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.

Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma.

The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties.

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.

Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

Archaeal-eubacterial mergers in the origin of Eukarya: phylogenetic classification of life.

DANA elements: a family of composite, tRNA-derived short interspersed DNA elements associated with mutational activities in zebrafish (Danio rerio).

Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer.

DNA damage enhances melanogenesis.

Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value.

An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing.

Clustered syk tyrosine kinase domains trigger phagocytosis.

Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.

Stimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channels.

Protein-protein interactions in eukaryotic transcription initiation: structure of the preinitiation complex.

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.

Role of hydrophobic interactions and desolvation in determining the structural properties of a model alpha beta peptide.

Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.

The wing of the enhancer-binding domain of Mu phage transposase is flexible and is essential for efficient transposition.

Origin and evolution of circular waves and spirals in Dictyostelium discoideum territories.

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

Genetic engineering of carbohydrate biosynthetic pathways in transgenic mice demonstrates cell cycle-associated regulation of glycoconjugate production in small intestinal epithelial cells.

Uptake of fluorescent dyes associated with the functional expression of the cystic fibrosis transmembrane conductance regulator in epithelial cells.

Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.

Myristate exchange on the Trypanosoma brucei variant surface glycoprotein.

Multiplex selection technique (MuST): an approach to clone transcription factor binding sites.

Phylogenetic resolution within the Elephantidae using fossil DNA sequence from the American mastodon (Mammut americanum) as an outgroup.

HLH106, a Drosophila transcription factor with similarity to the vertebrate sterol responsive element binding protein.

Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?

Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo.

A cell cycle-regulated bacterial DNA methyltransferase is essential for viability.

31P magnetic resonance spectroscopy of the Sherpa heart: a phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia.

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.

Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes.

Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake.

The chicken beta 2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: a small, G+C-rich gene with X and Y boxes in the promoter.

Preserved speech abilities and compensation following prefrontal damage.

The secreted Ipa complex of Shigella flexneri promotes entry into mammalian cells.

Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins.

A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern.

Neuronal abnormalities in microtubule-associated protein 1B mutant mice.

Substance P responsiveness of smooth muscle cells is regulated by the integrin ligand, thrombospondin.

A technique for detecting matrix proteins in the crystalline spicule of the sea urchin embryo.

Heteromeric connexons in lens gap junction channels.

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli.

A compositional map of human chromosome band Xq28.

Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo.

Antiproliferative properties of the USF family of helix-loop-helix transcription factors.

Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal human muscle.

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys.

Synergy between chronic corticosterone and sodium azide treatments in producing a spatial learning deficit and inhibiting cytochrome oxidase activity.

Short-term synaptic enhancement and long-term potentiation in neocortex.

Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle.

Cue recognition and cue elaboration in learning from examples.

Extending the chemistry that supports genetic information transfer in vivo: phosphorothioate DNA, phosphorothioate RNA, 2'-O-methyl RNA, and methylphosphonate DNA.

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

The in vitro ejection of zinc from human immunodeficiency virus (HIV) type 1 nucleocapsid protein by disulfide benzamides with cellular anti-HIV activity.

Improved antitumor activity of a recombinant anti-Lewis(y) immunotoxin not requiring proteolytic activation.

In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

Antigenic variation and the within-host dynamics of parasites.

Equine rhinovirus 1 is more closely related to foot-and-mouth disease virus than to other picornaviruses.

Transcription of tufA and other chloroplast-encoded genes is controlled by a circadian clock in Chlamydomonas.

Year: 1996 Volume: 93 Issue: 2

Year: 1996 Volume: 93 Issue: 1

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, B. Yamamoto, T. Copeland, T. Kamata, T. Kung, H. Subleski, M. Fusaki, N. Princler, G. L.
Description	Author Affiliation: Li B ( Biological Carcinogenesis and Development Program, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21702-1201, USA.);
Abstract	mSOS, a guanine nucleotide exchange factor, is a positive regulator of Ras. Fyn tyrosine protein kinase is a potential mediator in T-cell antigen receptor signal transduction in subsets of T cells. We investigated the functional and physical interaction between mSOS and Fyn in T-cell hybridoma cells. Stimulation of the T-cell antigen receptor induced the activation of guanine nucleotide exchange activity in mSOS immunoprecipitates. Overexpression of Fyn mutants with an activated kinase mutation and with a Src homology 2 deletion mutation resulted in a stimulation and suppression of the mSOS activity, respectively. The complex formations of Fyn-Shc, Shc-Grb2, and Grb2-mSOS were detected in the activated Fyn-transformed cells, whereas the SH2 deletion mutant of Fyn failed to form a complex with mSOS. Moreover, tyrosine phosphorylation of Shc was induced by the overexpression of the activated Fyn. These findings support the idea that Fyn activates the activity of mSOS bound to Grb2 through tyrosine phosphorylation of Shc. Unlike the current prevailing model, Fyn-induced activation of Ras might involve the stimulation of the catalytic guanine nucleotide exchange activity of mSOS.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adaptor Proteins, Signal Transducing Protein-Tyrosine Kinases Metabolism Proteins Proto-Oncogene Proteins Receptor-CD3 Complex, Antigen, T-Cell Receptors, Antigen, T-Cell T-Lymphocytes, Helper-Inducer Animals Enzyme Activation Eukaryotic Initiation Factor-2 GRB2 Adaptor Protein Gene Expression Guanine Nucleotide Exchange Factors Kinetics Mice Mutagenesis, Site-Directed Point Mutation Protein Binding Isolation & Purification Biosynthesis Proto-Oncogene Proteins C-fyn Immunology Recombinant Proteins Sequence Deletion Transfection Ras Guanine Nucleotide Exchange Factors Src Homology Domains Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Libarray of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in