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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Rando, Thomas A. Wilson-rawls, Jeanne Allen, Ronald E. Rogers, Erik Biressi, Stefano Beres, Brian J. George, Rajani M. Rawls, Alan Mulia, Amanda K. |
Description | Author Affiliation: George RM ( School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501.); |
Abstract | The adaptor protein Numb has been implicated in the switch between cell proliferation and differentiation made by satellite cells during muscle repair. Using two genetic approaches to ablate Numb, we determined that, in its absence, muscle regeneration in response to injury was impaired. Single myofiber cultures demonstrated a lack of satellite cell proliferation in the absence of Numb, and the proliferation defect was confirmed in satellite cell cultures. Quantitative RT-PCR from Numb-deficient satellite cells demonstrated highly up-regulated expression of p21 and Myostatin, both inhibitors of myoblast proliferation. Transfection with Myostatin-specific siRNA rescued the proliferation defect of Numb-deficient satellite cells. Furthermore, overexpression of Numb in satellite cells inhibited Myostatin expression. These data indicate a unique function for Numb during the initial activation and proliferation of satellite cells in response to muscle injury. |
ISSN | 00278424 |
e-ISSN | 10916490 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Issue Number | 46 |
Volume Number | 110 |
Language | English |
Publisher | National Academy of Sciences |
Publisher Date | 2013-11-01 |
Publisher Place | United States |
Access Restriction | Open |
Subject Keyword | Cell Proliferation Membrane Proteins Deficiency Muscle Development Physiology Nerve Tissue Proteins Regeneration Satellite Cells, Skeletal Muscle Analysis Of Variance Animals Barium Compounds Blotting, Western Body Weights And Measures Chlorides Flow Cytometry Fluorescent Antibody Technique Mice Mice, Knockout Genetics RNA Interference RNA, Small Interfering Reverse Transcriptase Polymerase Chain Reaction Metabolism Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
Content Type | Text |
Resource Type | Article |
Subject | Multidisciplinary |
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