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Content Provider | World Health Organization (WHO)-Global Index Medicus |
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Author | Zhou, Nuo Zan, Xiaoli Wang, Zheng Wu, Hua Yin, Dengke Liao, Chunyan Wan, Ying |
Description | Author Affiliation: Zhou N ( The Affiliated Stomatology Hospital, Guangxi Medical University, Nanning 530021, PR China.) |
Abstract | Galactosylated chitosan-polycaprolactone (Gal-CH-PCL) copolymers with a galactosylation degree of around 10% and varied PCL percentages less than 40 wt% were synthesized and used to produce nanoparticles for delivering curcumin. Some nanoparticles with encapsulation efficiency of 70% or higher and sizes changing from 100 to 250 nm were able to deliver curcumin in a controlled manner. PCL content in Gal-CH-PCLs was found to be a key factor for governing the release behavior of nanoparticles. Hepatocyte-targeted characteristic of nanoparticles was confirmed using human hepatocellular carcinoma (HepG2) cells. In comparison to free curcumin, curcumin-loaded Gal-CH-PCL nanoparticles well retained its anticancer activity. At an equivalent curcumin-dose of around 20 µg/mL that was found to be relatively safe to human normal liver cells, the results obtained from flow-cytometry revealed that some optimized Gal-CH-PCL nanoparticles showed more than 6-fold increasing abilities to induce the apoptosis and necrosis of HepG2 cells during 72 h treatment compared to free curcumin. |
File Format | HTM / HTML |
ISSN | 01448617 |
Issue Number | 1 |
Volume Number | 94 |
e-ISSN | 18791344 |
Journal | Carbohydrate Polymers |
Language | English |
Publisher | Elsevier |
Publisher Date | 2013-04-15 |
Publisher Place | Great Britain (UK) |
Access Restriction | Subscribed |
Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Chitosan Analogs & Derivatives Chemistry Curcumin Pharmacology Drug Carriers Galactose Hepatocytes Drug Effects Nanoparticles Polyesters Apoptosis Cell Survival Chemical Synthesis Metabolism Glycosylation Hela Cells Hep G2 Cells Physiology Humans Kinetics Particle Size Journal Article Research Support, Non-u.s. Gov't |
Content Type | Text |
Resource Type | Article |
Subject Domain (in MeSH) | Cells Eukaryota Organic Chemicals Macromolecular Substances Carbohydrates Pharmaceutical Preparations Physical Phenomena Chemical Phenomena Cell Physiological Phenomena Technology, Industry, and Agriculture |
Subject | Polymers and Plastics Materials Chemistry Organic Chemistry |
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