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Content Provider | IEEE Xplore Digital Library |
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Author | Pilla, P. Manzillo, P.F. Malachovska, V. Campopiano, S. Cutolo, A. Giordano, M. Cusano, A. |
Copyright Year | 2009 |
Description | Author affiliation: Institute for Composite and Biomedical Materials, National Research Council, Piazzale Tecchio, 80 - 80125 Naples, Italy (Malachovska, V.; Cutolo, A.) || Department for Technologies, University of Naples ¿Parthenope¿, Centro Direzionale Isola C4 - 80143, Italy (Manzillo, P.F.; Campopiano, S.) || Optoelectronic Division, Engineering Department, University of Sannio, Corso Garibaldi, 107 - 82100 Benevento, Italy (Pilla, P.; Giordano, M.; Cusano, A.) |
Abstract | In this work, we present preliminary results concerning the development of a platform for label-free biochemical sensing, based on overlayered Long Period Gratings (LPGs) working in transition mode. Nano-scale layers of Polystyrene (PS) with different thicknesses were deposited onto the same LPG to test the performances of the device in different operating points of its sensitivity characteristic, drastically modified by the modal transition phenomenon. The physical adsorption dynamic of Biotinylated Bovine Serum Albumin (BBSA) onto the PS surface and the subsequent binding of Streptavidin (SA) on the BBSA layer were recorded by monitoring the variation of LPG transmission dips spectral position. Experimental results demonstrated overlayered LPGs to be among the most sensitive transducers that can be employed in biosensing. Moreover wide margins of further optimization exist. |
Starting Page | 361 |
Ending Page | 366 |
File Size | 529961 |
Page Count | 6 |
File Format | |
ISBN | 9781424445486 |
ISSN | 19300395 |
DOI | 10.1109/ICSENS.2009.5398236 |
Language | English |
Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Publisher Date | 2009-10-25 |
Publisher Place | New Zealand |
Access Restriction | Subscribed |
Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
Subject Keyword | Biosensors Refractive index Testing Transducers Optical attenuators Optical films Fluorescence Fiber gratings Diffraction gratings Biomedical engineering |
Content Type | Text |
Resource Type | Article |
Subject | Electrical and Electronic Engineering |
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